mRNA
Enzymatic Capping: Process, Pros, and Cons
We have discussed the evolution of cap analogs and the new generation of fine-tuned cap analogs for different applications. Generally, there are two ways of capping mRNA produced from an IVT reaction. One way is co-transcriptionally capping where a cap analog is added to the IVT reaction and gets incorporated into the 5’- terminal of
mRNA
Areterna’s Caps and NTPs as Evaluated by a Customer
Areterna offers Cap Analogs, NTPs, and Modified NTPs for mRNA synthesis. Our products have been tested and accepted by over 200 companies worldwide. One of these companies shared with us how they decided to use our products.
mRNA
AI-Assisted Cap Analog Discovery Platform
We discussed our novel cap analogs, CAP4 and CAP5, in the last blog The Evolution of Cap Analogs, you may wonder how we discovered these unique molecules. Areterna’s engine of innovation is built upon our AI-Assisted Cap Analog Discovery Platform which integrates a design-build-test-learn machine learning process, comprising five key steps. Let’s delve into the
mRNA
The Evolution of Cap Analogs
Introduction In the intricate world of mRNA synthesis, the cap structure plays a pivotal role in regulating gene expression. Scientists have made significant strides in the development of various cap analogs to enhance mRNA stability, translational efficiency, and therapeutic potential. In this blog, we’ll delve into the different types of cap analogs—m7G cap, ARCA, CleanCap@,