Areterna's Messengers

To ensure effective in vivo delivery, mRNA vaccines rely on not only optimized antigen sequences but also a robust delivery system capable of overcoming extracellular barriers, facilitating endosomal escape, and evading intracellular immune responses. Lipid...

In recent years, mRNA vaccines and drugs have received widespread attention around the world. Areterna LLC is proud to introduce Fluc-eGFP mRNA (Catalog number: 11013-CAP), a cutting-edge tool to accelerate your mRNA research. This mRNA encodes both eGFP and...

In vitro transcription (IVT) remains the predominant method for large-scale mRNA synthesis due to its efficiency and scalability. However, a significant challenge associated with IVT is the residual double-stranded RNA (dsRNA) produced as a by-product. This dsRNA can...

In-vitro transcription (IVT) is a reactor-based scheme to manufacture RNA where cell-derived impurities or adventitious contaminants can be avoided thus making the manufacturing process GMP-friendly. The IVT reaction is often carried out at 37°C for 2...

We have discussed the evolution of cap analogs and the new generation of fine-tuned cap analogs for different applications. Generally, there are two ways of capping mRNA produced from an IVT reaction. One way is co-transcriptionally capping where a cap analog is added...

Areterna offers Cap Analogs, NTPs, and Modified NTPs for mRNA synthesis. Our products have been tested and accepted by over 200 companies worldwide. One of these companies shared with us how they decided to use our products.

We discussed our novel cap analogs, CAP4 and CAP5, in the last blog The Evolution of Cap Analogs, you may wonder how we discovered these unique molecules. Areterna’s engine of innovation is built upon our AI-Assisted Cap Analog Discovery Platform which integrates a...

Introduction In the intricate world of mRNA synthesis, the cap structure plays a pivotal role in regulating gene expression. Scientists have made significant strides in the development of various cap analogs to enhance mRNA stability, translational efficiency, and...