Areterna's Messengers

Enzymatic Capping: Process, Pros, and Cons

We have discussed the evolution of cap analogs and the new generation of fine-tuned cap analogs for different applications. Generally, there are two ways of capping mRNA produced from an IVT reaction. One way is co-transcriptionally capping where a cap analog is added...

AI-Assisted Cap Analog Discovery Platform

We discussed our novel cap analogs, CAP4 and CAP5, in the last blog The Evolution of Cap Analogs, you may wonder how we discovered these unique molecules. Areterna’s engine of innovation is built upon our AI-Assisted Cap Analog Discovery Platform which integrates a...

The Evolution of Cap Analogs

Introduction In the intricate world of mRNA synthesis, the cap structure plays a pivotal role in regulating gene expression. Scientists have made significant strides in the development of various cap analogs to enhance mRNA stability, translational efficiency, and...