DS0001
dsRNA detection kit (ELISA)
dsRNA Detection Kit (ELISA): detects dsRNA down to 0.01 pg/µl.
$1,400.00
View detailsCustom services · mRNA
Custom mRNA Services
One-stop mRNA solution, from GMP-grade raw materials to a finished LNP formulation. Our platforms cover sequence design, plasmid preparation, in vitro transcription, purification, LNP encapsulation and product testing, with traceability and data packages intended to support IND filings.
One-stop mRNA solution
Raw material supply
GMP-grade inputs for mRNA synthesis, including cap analogs, modified nucleotides, NTPs and custom monomers.
Technology platform
Covers the full mRNA development workflow: sequence design, plasmid preparation, in vitro transcription (IVT), purification, lipid nanoparticle (LNP) encapsulation and product testing.
CRO model
End-to-end services from sequence to formulation, with traceability and data packages intended to support IND filings.
Four platforms, sequence to release
HiSignal®, HiSynth® and HiTrans® take a construct from sequence design to a tested LNP formulation.
Design
Sequence engineering and plasmid construction.
Materials
GMP-grade NTPs, modified nucleotides and cap analogs.
Process
From linearized plasmid to encapsulated LNP.
Release
Quality control and stability studies.
HiSignal® Sequence Design Platform
- AI-assisted algorithms and validated databases support sequence engineering: antigen design, UTR optimization, codon adaptation and structural stability assessment.
- Epitope prediction, signal peptide screening, and joint optimization of stability and translation efficiency.
- Gene synthesis and cloning for plasmid construction.
HiSynth® Nucleic Acid Chemistry Platform
- GMP-compliant supply of mRNA synthesis materials: NTPs, modified nucleotides (pseudouridine, N1-methylpseudouridine, 5-methylcytidine) and cap analogs.
- Custom modified monomers, fluorescent nucleotides and specialty backbone derivatives.
- High purity, low endotoxin and complete COA documentation.
HiTrans® IVT & Encapsulation Platform
- Linearized plasmid prep, IVT optimization, co-transcriptional or enzymatic capping, purification (chromatography or ultrafiltration) and LNP encapsulation.
- Compatible with various lipid formulations and with microfluidic or impingement jet mixing.
- Scale from microgram to gram.
- Real-time monitoring of critical process parameters (CPPs) and critical quality attributes (CQAs): particle size, PDI, encapsulation efficiency and mRNA integrity.
HiSignal® Analytical Platform
- Quality control for mRNA drug substance and LNP formulations.
- Stability study design, with accelerated and long-term data to meet pharmacopoeia and regulatory guidelines.
What the analytical platform measures
Attributes tested on mRNA drug substance and LNP formulations.
| Attribute | Method / readout |
|---|---|
| Capping efficiency | LC-MS |
| Poly(A) tail length | LC-MS |
| Integrity | CE |
| Encapsulation efficiency | RiboGreen fluorescence |
| In vitro activity | Transfection efficiency, protein expression |
Residual impurities, sterility and endotoxin, and LNP characterization are also covered.
Order the materials directly
CAP3130
ARCA
ARCA cap analog for co-transcriptional capping.
$160.00
View details
Download our brochures
The Core Material for mRNA Synthesis in Vitro
PDF · 2.5 MB
Download our brochures
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