Custom services · Oligonucleotide
Custom Oligonucleotide Services
Custom raw materials across the oligonucleotide drug R&D chain, from monomers to complex conjugates. We support ASO, siRNA, miRNA, aptamers and other oligonucleotide drugs from discovery through commercial production.
Platform, portfolio and support
Expertise & platform
Covers the oligonucleotide drug R&D chain for custom raw materials.
Product portfolio
Spans monomers to complex conjugates: phosphoramidites, nucleosides, GalNAc conjugates, succinates, phosphorus reagents and enzymatic synthesis components.
Applications & support
Supports ASO, siRNA, miRNA, aptamers and other oligonucleotide drugs from discovery through commercial production.
Core raw material categories
- Phosphoramidites. Standard and modified, including 2′-F, 2′-OMe, 2′-MOE, LNA and ENA, with custom base or fluorescent modifications.
- Nucleosides.
- GalNAc conjugates. Multi-arm GalNAc conjugates.
- Succinates and solid supports. CPG and polymer supports.
- Phosphorus reagents.
- Enzymatic synthesis. Substrates and enzymes.
Chemical synthesis capabilities
Synthesis from milligram to kilogram scale, following QbD principles with process control and intermediate testing. Process routes are covered by multiple patents, and batch-to-batch consistency is controlled.
Custom service models
Dedicated teams handle each stage, from a first specification to production supply.
- Define the specification. Special modifications, purity specifications, packaging and delivery timelines.
- Evaluate synthetic routes. A dedicated team assesses the route for your target.
- Scale from lab to pilot.
- Collaborate on an FTE basis. For long-term or exploratory work, with expert resources and full facilities.
- Manage the project into production. Move from R&D to production supply.
Start from the catalog
Request a quotation
Tell us the target, the scale and the timeline you need. A scientist replies with pricing and a recommended route.